QB Issue Resolution:

With QuickBooks Mac it is possible to do this but only if the flash drive is formatted as HFS+ or better (specifically not MS-DOS). ¬†However… ¬†flash drives are very slow and I imagine the experience will be painful.

Most QuickBooks Mac files are less than 100MB which is almost nothing on today’s machines. And if it is one of the few really large files (500MB being about the largest) it really needs the performance of an internal drive (really it will benefit immeasurably from an internal SSD).

It is far better to move the file to your Documents directory and open it from there.

Resolution for Issue 'Can I work on a company backed up to USB flash drive and not download to computer?' available: Yes (Solved).
Source: Intuit Community forum.

Can I work on a company backed up to USB flash drive and not download to computer?: this issue or error code is a known issue in Quickbooks Online (QBO) and/or Quickbooks. Support for this issue is available either by self-service or paid support options. Experts are available to resolve your Quickbooks issue to ensure minimal downtime and continue running your business. First try to resolve the issue yourself by looking for a resolution described below. If it is a complex issue or you are unable to solve the issue, you may contact us by clicking here or by using other support options.

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