QB Issue Resolution:

Currently, we received a report that customers can’t open their QuickBooks application. Meanwhile, you can access QuickBooks through a browser.

 

You’ll want to┬ácontact our QuickBooks Online support team to link your account to the product investigation.

Resolution for Issue 'I updated to the newest version of QB and now I can’t open QB desktop. Online version is fine. Anyone else have this issue?' available: Yes (Solved).
Source: Intuit Community forum.

I updated to the newest version of QB and now I can’t open QB desktop. Online version is fine. Anyone else have this issue?: this issue or error code is a known issue in Quickbooks Online (QBO) and/or Quickbooks. Support for this issue is available either by self-service or paid support options. Experts are available to resolve your Quickbooks issue to ensure minimal downtime and continue running your business. First try to resolve the issue yourself by looking for a resolution described below. If it is a complex issue or you are unable to solve the issue, you may contact us by clicking here or by using other support options.

Support for Online version
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Error Recovery for Online version [Canada]
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Additional Support Options: