QB Issue Resolution:

There is not a way to auto-save transactions in QB. Great idea however. Please go to Help/Send Feedback Online and log this as a product suggestion.

Resolution for Issue 'Is it possible to set up an auto-save feature so that sales orders or purchase orders I am working on automatically save at certain intervals?' available: Yes (Solved).
Source: Intuit Community forum.

Is it possible to set up an auto-save feature so that sales orders or purchase orders I am working on automatically save at certain intervals?: this issue or error code is a known issue in Quickbooks Online (QBO) and/or Quickbooks. Support for this issue is available either by self-service or paid support options. Experts are available to resolve your Quickbooks issue to ensure minimal downtime and continue running your business. First try to resolve the issue yourself by looking for a resolution described below. If it is a complex issue or you are unable to solve the issue, you may contact us by clicking here or by using other support options.

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