QB Issue Resolution:

I’d recommend using eRequisition. It allows you to use the data from your company to create purchase requests, then send them for approval. The receiver will be notified via email that one is ready to be approved, and with just a few clicks they’ll be able to review all relevant information and make their decision. If approved, a new purchase order will be created your books.

You can use this article to find out more about the setup process, and connecting it with your QuickBooks Online company: Connect eRequisition with QBO

Resolution for Issue 'Is there any way to set up purchase order internal approvals before sending out to vendors within quickbooks online?' available: Yes (Solved).
Source: Intuit Community forum.

Is there any way to set up purchase order internal approvals before sending out to vendors within quickbooks online?: this issue or error code is a known issue in Quickbooks Online (QBO) and/or Quickbooks. Support for this issue is available either by self-service or paid support options. Experts are available to resolve your Quickbooks issue to ensure minimal downtime and continue running your business. First try to resolve the issue yourself by looking for a resolution described below. If it is a complex issue or you are unable to solve the issue, you may contact us by clicking here or by using other support options.

Support for purchase order approval
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Error Recovery for purchase order approval [Canada]
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