QB Issue Resolution:

the requirement for a home office is that there is a dedicated space used only for business, so no you can not

https://www.irs.gov/businesses/small-businesses-self-employed/simplified-option-for-home-office-dedu…

Resolution for Issue 'We have moved into a fifth wheel, is there a way to classify a portion of this as a home office, and or a portion of value as a write off, will be a brand new purchase.' available: Yes (Solved).
Source: Intuit Community forum.

We have moved into a fifth wheel, is there a way to classify a portion of this as a home office, and or a portion of value as a write off, will be a brand new purchase.: this issue or error code is a known issue in Quickbooks Online (QBO) and/or Quickbooks. Support for this issue is available either by self-service or paid support options. Experts are available to resolve your Quickbooks issue to ensure minimal downtime and continue running your business. First try to resolve the issue yourself by looking for a resolution described below. If it is a complex issue or you are unable to solve the issue, you may contact us by clicking here or by using other support options.

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