QB Issue Resolution:

Yes, pay events should be sent after every pay run (from the day you complete a pay run until the day you process the pay). – https://quickbooks.intuit.com/community/Payroll-and-STP/Create-and-lodge-a-pay-event/m-p/27536

Resolution for Issue 'We normally have 3 pay run every month. Do we send it 3 times a month too?' available: Yes (Solved).
Source: Intuit Community forum.

We normally have 3 pay run every month. Do we send it 3 times a month too?: this issue or error code is a known issue in Quickbooks Online (QBO) and/or Quickbooks. Support for this issue is available either by self-service or paid support options. Experts are available to resolve your Quickbooks issue to ensure minimal downtime and continue running your business. First try to resolve the issue yourself by looking for a resolution described below. If it is a complex issue or you are unable to solve the issue, you may contact us by clicking here or by using other support options.

Support for pay events
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Error Recovery for pay events [Canada]
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